ISSN 2736-1756
Research Article
Advanced Journal of Microbiology Research Vol. 2002
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2002 International Scholars Journals
Monoterpenes reduced adducts formation in rats exposed to aflatoxin B1
J. Abiodun Elegbede1* and Michael N. Gould2
1UNLV Cancer Institute/Chemistry Department, University of Nevada Las Vegas, 4505 Maryland Parkway, Las Vegas, NV 89154-4003
2McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, WI 53706-1599
Accepted 13 November 2002
Abstract
Perillyl alcohol and d-limonene are naturally occurring plant compounds that exhibited anti-carcinogenic activities in mammary tumor models. The effects of these monoterpenes at the initiation stage of aflatoxin B1-induced hepatocarcinogenesis were investigated. Male F344 rats were fed Control or treatment diets throughout the study and exposed to aflatoxin for 5 days. Three days after the last aflatoxin dose, blood and liver samples were obtained. Analysis of liver samples showed that both limonene and perillyl alcohol significantly inhibited (p<0.05) aflatoxin-DNA adducts formation in hepatocytes. The monoterpenes may have potential for use as chemopreventive agent against aflatoxin-induced liver cancer.
Keywords: Aflatoxin B1, hepatocarcinogenesis, monoterpenes, chemoprevention.
J. Abiodun Elegbede*, Michael N. Gould
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Research Article
Advanced Journal of Microbiology Research Vol. 2002
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2002 International Scholars Journals
Physiological and molecular insights into drought tolerance
Sagadevan G Mundree *, Bienyameen Baker, Shaheen Mowla, Shaun Peters, Saberi Marais, Clare Vander Willigen, Kershini Govender, Alice Maredza, Samson Muyanga, Jill M Farrant and Jennifer A Thomson
Department of Molecular and Cell Biology, University of Cape Town, Private Bag, Rondebosch, 7701 South Africa
Accepted 8 November 2002
Abstract
Water is a major limiting factor in world agriculture. In general, most crop plants are highly sensitive to even a mild dehydration stress. There are however, a few genera of plants unique to Southern Africa, called “resurrection plants” which can tolerate extreme water loss or desiccation. We have used Xerophyta viscosa, a representative of the monocotyledonous resurrection plants to isolate genes that are associated with osmotic stress tolerance. Several genes that are differentially expressed, and that confer functional sufficiency to osmotically-stressed Escherichia coli are being studied at the molecular and biochemical levels. In this review, we use this as a basis to discuss the physiological and molecular insights into drought tolerance.
Key words: Drought stress, reactive oxygen species, osmoprotectants, abscisic acid, transcription factors.
Alice Maredza, Jill M Farrant and Jennifer A Thomson, Samson Muyanga, Saberi Marais, Shaheen Mowla, Kershini Govender, Bienyameen Baker, Clare Vander Willigen, Sagadevan G Mundree *, Shaun Peters
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