International Journal of Obstetrics and Gynecology

International Journal of Obstetrics and Gynecology ISSN: 2326-7234 Vol.  3 (4) pp. 090-094, June, 2015. © International Scholars Journals

Full length Research paper

Intensity of maternal serum leptin in relentless preeclamptic pregnant women in early postpartum stage

*Cemal İpekçi Kutlar, Abdi W. Erberk and Abdulhak M. Jonturk

Department of Gynecology and Obstetrics, Faculty of Medicine, Atatürk University, Erzurum, Turkey.

E-mail: [email protected] 

Accepted 13 May, 2015

Abstract 

The aim of this study is to determine early postpartum maternal serum leptin levels in severe preeclamptic pregnant women. This study was planned as a prospective controlled trial. The patient and control groups in the study were composed in the period between January 2003 and January 2004. The study, performed in the Department of Perinatology of SSK Bakirkoy Maternal Hospital and Women and Child Diseases Education Hospital, consists of forty-four singleton pregnant women giving birth after hospitalized with diagnosis of severe preeclampsia and forty-four normotensive singleton pregnant women who were found to have healthy pregnancy on examination and analysis before given birth. The venous blood of all pregnants was taken from the antecubital region in early postpartum period while they were all hungry. We studied the relation between demographic data, biochemical data, baby weight at birth and the serum leptin levels. Comparing the preeclamptic pregnant women with control group in terms of leptin, although leptin levels in severe preeclamptic pregnant women were found to be higher than control group, statistically, no significant difference was determined (p: 0.069). In severe preeclamptic group, baby weight at birth was found to be significantly lower (p: 0.000). Evaluating all pregnant women, it was determined that there has been a positive significant relation between serum leptin levels and diastolic tension (p: 0.044), urea (p: 0.019), creatinine (p:0.000), uric acid (p: 0.000); and a negative significant relation between serum leptin levels and baby weight at birth (p: 0.038). No relation was found between the leptin level and the gender of infants. No significant difference of early postpartum maternal serum leptin levels between severe preeclamptic group and normotensive group was determined.

Key words: Preeclampsia, early postpartum stage, serum leptin levels, severe preeclamptic pregnant women.

International Journal of Obstetrics and Gynecology ISSN: 2326-7234 Vol.  3 (4) pp. 081-089, June, 2015.  © International Scholars Journals

Full Length Research Paper

Relative assessment of abnormalities patterns in hysterosalpingography, diagnostic laparoscopy and hysteroscopy with infertility cases in women in Nigeria

Omelu Clever, Adajarha Esther, Owungalo Ebuka and Majimeta Anthony

Departments of Radiology, Obstetrics and Gynecology, Delta State University, Abraka, Nigeria.

E-mail: [email protected]

Accepted 5 May, 2015

Abstract 

Laparoscopy and hysteroscopy procedures commenced recently in our center and no study has been done on them yet. Also, there is paucity of information in our environment on comparison of laparoscopy/hysteroscopy findings with hysterosalpingography (HSG) amongst infertile women. The purpose of this study was to evaluate pattern of the abnormalities detected on HSG in infertile women and to compare them with laparoscopy and hysteroscopy findings. A prospective study of 220 consecutive patients who had HSG between December, 2011 and May, 2013, at Department of Radiology, Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria was conducted. Clinical notes and radiological findings were analyzed for demographic data, uterine status, tubal and pelvic abnormalities. Findings were correlated with those of laparoscopy and hysteroscopy. Data was analyzed using EPI Info version 3.3.2 for windows. Of the 72 women with tubal occlusion on HSG, 46 (63.89%) women had laparoscopy with dye test. HSG demonstrated unilateral tubal occlusion in 35 (76.09%) women and bilateral tubal occlusion in 11 (23.91%) women. The laparoscopy with dye test also demonstrated unilateral tubal occlusion in 34 (73.91%) women and bilateral tubal occlusion in 10 (21.74) women. The difference in the findings of both tests on tubal patency was not statistically significant (p>0.05). All the 26 women with uterine adhesion on HSG had diagnostic hysteroscopy which confirmed all the cases. There was no difference in the findings of both tests (p>0.05). Both HSG and diagnostic laparoscopy are effective in evaluating tubal patency with no significant difference in accuracy. Also both HSG and hysteroscopy are effective in evaluating intrauterine adhesions with no difference in accuracy.

Key words: Abnormalities, hysterosalpingography, laparoscopy/hysteroscopy, infertility.

International Journal of Obstetrics and Gynecology ISSN: 2326-7234 Vol.  3 (3) pp. 077-080, May, 2015.© International Scholars Journals

Full Length Research Paper

Joined oral and vaginal misoprostol use in remedial terminations at 14 to 28 weeks of gestation

Cemal İpekçi Kutlar

Department of Gynecology and Obstetrics, Faculty of Medicine, Atatürk University, Erzurum, Turkey.

E-mail: [email protected]

Accepted 19 April, 2015

Abstract 

This study involved an investigation of the effectiveness and complications of oral and vaginal misoprostol use on the termination of second trimester pregnancies. A total of 103 cases were recruited from the medical records of the Gynecology and Obstetrics Clinic of Taksim Research and Training Hospital and Şırnak İdil State Hospital. Women underwent therapeutic termination of pregnancy between the 14 to 28th week of gestation using the defined combined misoprostol regimen. After the women were admitted, 200 μg vaginal (100 μg intracervical, 100 μg into the posterior fornix), 200 μg oral doses and 200 μg of sequential doses were administered in the 2nd and 4th hour. Subjects were excluded from the study if they were out of the defined gestational weeks using additional drugs with misoprostol; their data has not been recorded in detail. Of the 103 cases, 86 had an abortion within 24 h and the mean expulsion time was calculated as 15.42 ± 7.14 h (min 6.39 to max 20.03) in this group. The success rate for the 24 h was found to be 83.4%. Six more cases had an abortion when the second dose was given. The mean expulsion time was found to be 9.31 ± 3.26 h (min 6.45 to max 13.21) for the second 24 h. The success rate over 48 h rose to 89.3%. The total expulsion time was 18.30 ± 8.74 h. There was a history of previous caesarean sections in 2 out of 11 cases that did not have an abortion and one of these cases underwent a hysterotomy. The pregnancy was terminated by evacuation and curettage, as abortion did not occur despite 3 different high dose misoprostol regimens as in the other cases. Pregnancies of the remaining 9 cases were terminated with different misoprostol doses, oxytocin infusion and the evacuation and curettage method. When complication rates were evaluated, analgesic requiring pain (18.4%) was the leading complication, followed by nausea (11.6%), fever (7.7%), headaches and dizziness (5.8%), transfusion-requiring haemorrhage (3.8%) and diarrhea (1.9%). Uterine rupture or death did not occur. A combined misoprostol regimen is relatively safe with acceptable side effects when used carefully for the termination of second trimester pregnancies.

Keyword: Misoprostol, Pregnancy Trimester. Second, Termination of Pregnancy, Mean Expulsion Time, Medical Termination, Vacuum Curettage, Side Effects

International Journal of Obstetrics and Gynecology ISSN: 2326-7234 Vol.  3 (3) pp. 072-076, May, 2015.  © International Scholars Journals

Full Length Research Paper

Exploratory endometriosis reduction in rats treated with pioglitazone

*Zhuo Zetian, Jiang S. Kar-wai and Guan V. Salim

Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong, China.

E-mail: [email protected]

Accepted 7 April, 2015

Abstract

The objective of this paper was to assess the effectiveness of the pioglitazone on endometriosis in rats. The study was performed on 24 Wistar rats. Endometriosis induction was performed in 24 rats, which were divided into three groups: group I (model group); and group II, the treatment group, comprising the other 12 rats. After 3 months, pioglitazone was performed in all animals. Pioglitazone treatment seems to be effective in treatment of endometriosis.

Key words: Pioglitazone, endometriosis, uterine implant, NF-_kB p65, I_kBα.

International Journal of Obstetrics and Gynecology ISSN: 2326-7234 Vol.  3 (2) pp. 068-071, April, 2015. © International Scholars Journals

Full Length Research Paper

The investigation of relationship between bacterial vaginosis and cervical intraepithelial neoplasia at Xiangya Hospital (Changsha-Hunan, China)

*Zhuo Zetian, Jiang S. Kar-wai and Guan V. Salim

Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong, China.

E-mail: [email protected] 

Accepted 25 March, 2015

Abstract

This study was to explore the relationship between bacterial vaginosis and cervical dysplasia. Vaginal discharge gram stain, liquid-based thinlayer cystoFast test (TCT), human papilloma virus (HPV) types 16, 18 test, colposcopy and directed biopsy were performed among 46 patients with cervical dysplasia served as investigate group and 100 patients with cervicitis served as control group. There was statistically significant increase in the incidence of bacterial vaginosis among cervical dysplasia group (52.18%) compared with control group (10.0%) (P<0.05). Their human papilloma virus (HPV) 16, 18 positive rates were 60.9 and 3% respectively (P<0.05). Human papilloma virus (HPV) types 16, 18 and bacterial vaginosis co-infection incidence were 41.3 and 0% respectively (P< 0.05). Both human papilloma virus (HPV 16, 18) and bacterial vaginosis (BV) negative results were 28.3 and 87.0% (P<0.05). Logistic regression test indicated that human papilloma virus (HPV) 16, 18 and bacterial vaginosis were independent risk factors for cervical dysplasia. Bacterial vaginosis facilitates the infection of HPV type 16, 18 and thus enhances development and progression of cervical dysplasia.

Key words: Bacterial vaginosis (BV), Human papilloma virus types 16, 18 (HPV 16, 18), cervical dysplasia (CIN).

International Journal of Obstetrics and Gynecology ISSN: 2326-7234 Vol.  3 (2) pp. 064-067, April, 2015. © International Scholars Journals

Full Length Research Paper

Body mass file (BMI) related insulin resistance in polycystic ovarian disorder among patients alluded to gynecology center of Imam Reza Hospital, Tehran, Iran

*Babak M. Amanpour, Reza Kiarostami and Mehran Makhmalbaf

Department of Obstetrics and Gynecology, Payame Noor University, Tehran, Iran.

Accepted 18 March, 2015

E-mail: [email protected]

Abstract

Polycystic ovarian syndrome (PCOs) is one of the commonest endocrinopathies of women. The present work has been undertaken with an aim to study insulin resistance rate among army personnel families. Out of 108 women suffering from oligomenorrhea and hirsutism referred to gynecology clinic of Imam Reza hospital from 2009 to 2010, 58 patients with PCOs were evaluated for insulin resistance. Their disease was diagnosed clinically and confirmed by laboratory findings. The patients fasting blood sugar (FBS) was measured to be 81 to 103 with mean of 91.44 ± 6.52. Insulin level of their fasting blood (FBI) was 3.1 to 33 with mean of 10.95 ± 7.53. FBS/FBI ratio ranged from 2.87 to 31.6 with mean of 12.54 ± 7.98. The co-relational analysis reveals a positive relationship between insulin resistance and body mass index (BMI; normal, overweight and obese). There was a significant association between these two ordinal variables (Spearman’s Correlation Coefficient is 0.59, P < 0.01). Leutinizing hormone/follicle stimulating hormone (LH/FSH) ratio is not significantly related with BMI (P = 0.65) and no significant relationship was observed between age groups and LH/FSH ratio (P = 0.76). The results achieved by two-way analysis of variance (ANOVA), that is, the F-values given in the Tests of Between-Subjects Effects indicate that the contribution of age group to ANOVA is not significant (F = 0.160, P = 0.852). The level of significance between BMI and FBS/FBI is 0.699 (F = 0.360). In addition to the main effects of both variables, there is no significant interaction. 6% of overweight and 39% of our obese patients were resistant to insulin, while no resistance to insulin was observed among cases with normal BMI.

Key words: Polycystic ovarian syndrome (PCOs), insulin resistance, diabetes, body mass index (BMI), infertility.