ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 12 (12), pp. 001-004, December, 2018. © International Scholars Journals
Full Length Research Paper
Synergistic effects of glucan and resveratrol
Vaclav Vetvicka1* and Zuzana Vancikova2
1Department of Pathology, University of Louisville, Louisville, KY 40202, USA.
21st Medical Faculty, Department of Pediatrics, Thomayer University Hospital, Prague, Czech Republic.
Accepted 12 April, 2018
Abstract
Recent data showing that glucan stimulates defense reactions in plants through synthesis of resveratrol, led us to study the possible synergetic effects of a glucan-resveratrol complex on immune reactions in mice. We measured phagocytic activity, expression of CD4 marker on spleen cells, IL-2 secretion and antibody response. In all cases we confirmed the stimulatory effects of glucan. Resveratrol alone had either limit or has no effect. However, a combined preparation showed very strong synergetic effects. Our data support further studies of these two natural immunomodulators.
Key words: Glucan, resveratrol, phagocytosis, IL-2, immune reactions, macrophage, antibody.