ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 13 (4), pp. 001-005, April, 2019. © International Scholars Journals
Full Length Research Paper
Cytotoxicity and antimicrobial activity of Teucrium scordium L. (Lamiaceae) extracts
Tatjana Kundakovi 1*, Marina Milenkovi 2, Aleksandra Topi 3, Tatjana Stanojkovi 4, Zorica Jurani 4 and Branislava Lakuši 5
1Department of Pharmacognosy, Faculty of Pharmacy, 11000 Belgrade, Serbia.
2Department of Microbiology and Immunology, Faculty of Pharmacy, 11000 Belgrade, Serbia.
3Department of Medical Biochemistry, Faculty of Pharmacy, 11000 Belgrade, Serbia.
4Institute for Oncology and Radiology of Serbia, 11000 Belgrade, Serbia.
5Department of Botany, Faculty of Pharmacy, 11000 Belgrade, Serbia.
Accepted 03 April, 2019
Abstract
Cytotoxicity and antimicrobial activity of cyclohexane, dichlormethane and methanol extracts of Teucrium scordium subspec. scordioides was studied. Cyclohexane and dichlormethane extracts of T. scordium possessed high citotoxicity against MDA-MB- 361 cells (IC50=130.33±0.1 g/ml and IC50=189.89±3.99 g/ml, respectively). Dichlormethane extract was more effective against MDA-MB-453 cell line (IC50=130.33 ± 0.1 g/ml). The methanol extract of T. scordium possessed no cytotoxicity against breast cancer cell lines, MDA-MB-361 and MDA-MB-453. Herb extracts of T. scordium have shown weak antibacterial activity on Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Bacillus subtilis with no activity against Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Enterococcus faecalis, and Candida albicans.
Key words: Teucrium scordium subsp. scordioides, cytotoxicity, antimicrobial activity.