ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2012
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2012 International Scholars Journals
Full Length Research Paper
Studies on immuno-bioactivities of Nyctanthes arbor-tristis (Oleaceae)
M. Kannan1*, A.J.A. Ranjit Singh2, T.T. Ajith Kumar3, P. Jegatheswari4 and S.Subburayalu5
1Microbiology Department, V.H.N.S.N.College, Virudhunagar-626 001, India.
2Department of Biology, Sri Paramakalyani College, Alwarkurichi–627412 India.
3CAS in Marine Biology, Annamalai University, Parangipettai – 608 502, India.
4Dhanalakshmi Srinivasan College for Women, Perambalur-621 212, India.
5K.R College of Arts and Science, Kovil Patti – 628 503, India.
Accepted 31 January, 2012
Abstract
In this study the immunomodulatory potential of an Indian medicinal plant, Nyctanthes arbor-tristis L. (Oleaceae), was investigated. The leaf extracts of N. arbor-tristis is used to treat arthritis, lung injury and some painful conditions such as cancer, chronic fever and rheumatism. An ethanolic extract of N. arbor-tristis (NAEE) was screened in rats for humoral and cell-mediated immune responses. Oral administration of the NAEE to rats at a dose of 50, 100, 150 and 200 mg/kg significantly enhanced the circulating antibody titre when challenged with sheep red blood cells (SRBC) and heat -killed Salmonella antigens. The chronic administration of NAEE increased the total counts of white blood cells (WBC) and potentated the delayed-type hypersensitivity (DTH) reactions. The present study confirms the strong immuno-bioactivities in extracts of Nyctanthes arbor-tristis L.
Key words: Immuno-bioactivities, Nyctanthes arbor-tristis, anti inflammatory, humoral immunity, delayed-type hypersensitivity.