ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 12 (4), pp. 001-004, April, 2018. © International Scholars Journals
Full Length Research Paper
In vitro interaction of combined plants: Tinospora crispa and Swietenia mahagoni against Methicillin-resistant Staphylococcus aureus (MRSA)
N. T. Al- alusi1*, F. A. Kadir2, S. Ismail1 and M. A. Abdullah1
1Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
2Department of Anatomy, Faculty of Medicine, University of Kebangsaan, Malaysia, 50300, Kuala Lumpur, Malaysia
Accepted 17 January, 2018
Abstract
This study has carried out to evaluate the antibacterial effect and the interaction between Tinospora crispa and Swietenia mahagoni extracts against resistant strains of Methicillin-resistant Staphylococcus aureus (MRSA). The minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) were determined in the setting of clinical MRSA isolates. Separated and mixture forms of T. crispa and S. mahagoni extracts were assayed to determine their antibacterial activity against eight clinical MRSA isolates. The extracts of T. crispa and S. mahagoni in separated forms were effective against MRSA strains. However, no interaction was found in the two plants combination. In conclusion, T. crispa and S. mahagoni are potential as anti MRSA agents, but the mixture of T. crispa and S. mahagoni has no synergism against MRSA strains.
Key words: Anti methicillin-resistant Staphylococcus aureus (MRSA), ethanolic extract, Swietenia mahagoni, Tinospora crispa, synergism.