ISSN 2169-3048
International Journal of Biochemistry and Biotechnology ISSN 2169-3048 Vol. 7 (9), pp. 869-875, September, 2018. © International Scholars Journals
Full Length Research Paper
A study of the protective effects of betaine administration against isoprenaline-induced myocardial infarction in rats
B. Ganesan1,2, R. Rajesh1,3 , R. Anandan 2,* and N. Dhandapani1,4
1Vinayaka Mission University, Ariyanoor, Salem-636308, Tamil Nadu, India.
2Biochemistry and Nutrition Division, Central Institute of Fisheries Technology, Matsyapuri (PO), Cochin-682029, India.
3Quality Assurance and Management Division, Central Institute of Fisheries Technology, Matsyapuri (PO), Cochin- 682029, India.
4Department of Pharmaceutical Chemistry, R.V.S College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, India.
*Corresponding author. E-mail: [email protected] or [email protected] Tel: +91-484-2666845. Fax: +91 484-2668212.
Accepted 11 July, 2018
Abstract
The protective effect of betaine administration on changes in the levels of protein, glycoproteins and amino acids was studied in isoprenaline-induced myocardial infarction in rats as an animal model of myocardial infarction in man. Oral pre-treatment with betaine significantly (P<0.05) attenuated the isoprenaline-induced rise in the levels of troponin-T and creatine phosphokinase (CPK). Oral supplementation of betaine also significantly (P<0.05) counteracted the isoprenaline-induced alterations in the levels of amino acids (taurine, aspartate, glutamate, arginine, hydroxy proline and homocysteine), protein content, glycoprotein components (hexose and hexosamine) and lipid peroxidation in the heart tissue and maintained their levels comparable to that of control animals. The results indicated that the overall cardioprotective effect of betaine was probably related to its ability to strengthen the myocardial membrane by its membrane stabilizing action or to a counteraction of free radicals by its antioxidant property.
Key words: Betaine, myocardial infarction, isoprenaline, glycoproteins, lipid peroxidation.