ISSN 2167-0404
International Journal of Medicine and Medical Sciences ISSN: 2167-0404 Vol. 3 (6), pp. 012-023, December, 2013.© International Scholars Journals
Full Length Research Paper
The role of vital exhaustion in cardiovascular risk in open population of 25–64-year-old men in Russia/Siberia (WHO MONICA-Psychosocial Program)
Valery Gafarov,1,2 Mikhail Voevoda,2,3 Elena Gromova,1,2 Vladimir Maksimov,2,3
Igor Gagulin,1,2 Nikolai Yudin,3 Almira Gafarova,1,2 and Tatiana Mishakova3
1Federal State Budgetary Institution the Research Institute of Internal Medicine of Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
2The Interdepartmental Laboratory of Cardiovascular Disease Epidemiology of Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
3Cytology and Genetics Institute of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
*Corresponding Author. Email: [email protected]
Accepted 22 September, 2013
Abstract
Objective of the study was to elucidate prevalence rates of vital exhaustion (VE), its effects on cardiovascular disease (CVD) risks, and genetic traits in open population of 25–64-year-old men in Russia/Siberia (Novosibirsk). Random representative sample of 25–64-year-old men was studied in a framework of WHO MONICA-Psychosocial Program (MOPSY). Maastricht Questionnaire (MQ) was used to assess VE. Genotyping of VNTR polymorphisms in DRD4 and DAT genes was performed. All new cases of arterial hypertension (AH), myocardial infarction (MI), and stroke were registered in people without CVD from 1994 to 2008. Data showed that VE rate was 66.8% in study population. Hazard ratio was significantly increased (AH: HR = 3.2; MI: HR = 2.7; stroke: HR = 3.2) in men with VE compared with VE-free individuals during the first five years of observation. Multifactorial modeling showed that VE together with concomitant social gradient determined development of AH, MI, and stroke in open male population. Allele 7 of DRD4 and genotype 9/9 of DAT gene were associated with high level of VE. Open population of men showed high level of VE, predictor for risk of developing CVD. Vital exhaustion was significantly associated with certain VNTR polymorphisms of DRD4 and DAT gens.
Key words: Vital exhaustion, arterial hypertension, myocardial infarction, DRD4 gene, DAT gene.