Frontiers of Agriculture and Food Technology

Frontiers of Agriculture and Food Technology ISSN 7295-2849 Vol. 10 (2), pp. 001-005, February, 2020. © International Scholars Journals

Full Length Research Paper

In vitro trypanocidal effect of methanolic extract of some Nigerian savannah plants 

S.E. Atawodi^1*, T. Bulus¹, S. Ibrahim¹, D.A. Ameh¹, A.J. Nok¹, M. Mamman², M. Galadima³

¹Biochemistry Department, Ahmadu Bello University, Zaria, Nigeria.

²Veterinary Physiology and Pharmacology Department, Ahmadu Bello University, Zaria, Nigeria.

³Microbiology Department, Ahmadu Bello University, Zaria, Nigeria.

Accepted 10 August, 2019

Abstract

Methanol extracts from twenty three plants harvested from the Savannah vegetation belt of Nigeria were analyzed in vitro for trypanocidal activity against Trypanosoma brucei brucei and Trypanosoma congolense at concentrations of 4 mg/ml, 0.4 mg/ml and 0.04 mg/ml. Extracts of Khaya senegalensis, Piliostigma reticulatum, Securidaca longepedunculata and Terminalia avicennoides were strongly trypanocidal to both organisms while extracts of Anchomanes difformis, Cassytha spp, Lannea kerstingii, Parkia clappertioniana, Striga spp, Adansonia digitata and Prosopis africana were trypanocidal to either T. brucei brucei or T. congolense. These findings provide evidence of the effects of some plants in the traditional management of trypanosomiasis.

Key words: Savannah, medicinal plants, trypanocidal effects, trypanosomiasis, trypanosome, in vitro model.