ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2017
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2017 International Scholars Journals
Full Length Research Paper
Protective effect of Glycyrrhiza glabra polysaccharides against carbon tetrachloride-induced liver injury in rats
Liang Renjie*, Shi Shidi and Sun Changsen
School of Life Science, Taizhou University, Zhejiang, 317000, P. R. China.
Accepted 5 July, 2017
Abstract
The objective of the present study was to investigate potential of Glycyrrhiza glabra polysaccharides to offer protection against acute liver injury in rats. Rats were administered a single oral dose carbon tetrachloride (CCl4, 640 mg/kg b.w., 1:1 in groundnut oil) and sacrificed 7 days of post-treatment. Hepatic damage was assessed by employing biochemical parameters. Our results demonstrated that treatment of rats with G. glabra polysaccharides significantly prevented the increased activities of and aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP and LDH in serum. G. glabra polysaccharides treatment also restored CCl4-induced altered caspase-3, TGF- 1 and TGF- 1 mRNA. Our findings provide evidences to demonstrate that G. glabra polysaccharides treatment significantly offsets CCl4-induced liver injury in rats.
Key words: Glycyrrhiza glabra polysaccharides, rat, TGF- 1 mRNA, aspartate aminotransferase (AST), carbon tetrachloride.