ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 13 (1), pp. 001-005, January, 2019. © International Scholars Journals
Full Length Research Paper
Antimicrobial activities of the whole plant of Cestrum nocturnum against pathogenic microorganisms
Murad Ali Khan1*, Humaira Inayat2,3, Haroon Khan4,5, Mohammmad Saeed4, Ikhtair Khan3 and Inayat-Ur-Rahman2
1Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan.
2Pakistan Council of Scientific and Industrial Research Laboratories Complex, Jamrud Road, Peshawar, Pakistan.
3Department of Chemistry University of Peshawar, Peshawar 25120, Pakistan.
4Department of Pharmacy University of Peshawar, Peshawar 25120, Pakistan.
5Gandhara College o f Pharmacy, Gandhara University, Peshawar, Pakistan.
Accepted 22 January, 2019
Abstract
The crude methanol extract of the whole plant of Cestrum nocturnum L. (Solanaceae) and its subsequent fractions were tested against various bacterial and fungal strains. With the exception of Salmonella typhi, the tested samples showed marked antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aurous, Bacillus subtilis, Escherichia coli and Shigella flexenari. The minimum inhibitory concentrations (MICs) ranged from 19 to 280 µg/ml. The crude extract and fractions were also susceptible to Candida species and Microsporium canis. The minimum inhibitory concentrations (MICs) for various fungi ranged from 170 to 290 µg/ml. In phytochemical analysis, the crude form and fractions of plant showed the presence of various phytochemical chemical groups like glycosides, alkaloids, saponins, phenols, flavonoids, sterols and tannins. Therefore, the current findings can be attributed to these groups.
Key words: Cestrum nocturnum L., antibacterial, antifungal, phytochemicals.