ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2013
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2013 International Scholars Journals
Review
Multidrug resistance in Pseudomonas aeruginosa: Insights into the molecular mechanisms
Sriram Seshadri* and Chintan Chhatbar
Department of Biochemistry and Biotechnology, Institute of Science, Nirma university of Science and Technology, Ahmedabad, S G Highway, Ahmedabad - 321481, Gujarat, India.
Accepted 4 May, 2013
Abstract
Pseudomonas aeruginosa is commonly found in chronic lung infections such as cystic fibrosis and others. Intrinsic antibiotic resistance of P. aeruginosa accompanied by its ability to acquire resistance via mutations and adapt to the heterogeneous and dynamic environment of chronically infected lungs are major threats and reasons for the ultimate failure of the current antibiotic therapies in eradicating the infection from lungs. New insights at molecular levels in the process of accumulating such beneficial mutations at faster rates, termed as hypermutation have allowed us to understand the high acquired resistance of this opportunistic pathogen. Also, these understandings will allow us to develop new therapeutic strategies to combat chronic infections.
Key words: Pseudomonas aeruginosa, chronic lung infections, multi drug resistance, hypermutation.