ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 12 (6), pp. 001-007, June, 2018. © International Scholars Journals
Full Length Research Paper
Fusidic acid-resistant methicillin-sensitive Staphylococcus aureus isolates in community of Casablanca (Morocco)
Mohamed Elazhari1,2*, Driss Elhabchi3, Khalid Zerouali4, Noureddine Dersi1, Jean David Perrier-Gros-Claude1,5, Sanaa Bouhali Zriouil4, Mohammed Hassar1,5, Rachid Saile2 and Mohammed Timinouni5
1Laboratoire de Bactériologie Médicale, Centre de Biologie Médicale, Institut Pasteur du Maroc, 1 place Louis Pasteur, Casablanca-20360, Marocco.
2Département de Biologie, Faculté des Sciences Ben M'Sik, Université Hassan II, UFR Biologie et Santé, Casablanca, Marocco.
3Laboratoire de Bactériologie, Département de sécurité alimentaire et d’environnement, Institut Pasteur du Maroc, 1 place Louis Pasteur, Casablanca-20360, Marocco.
4Laboratoire de Bactériologie, Faculté de Médecine et de Pharmacie, Université Hassan II, Rue Tarik Bnou Zyad, Casablanca-20360, Marocco.
5Laboratoire de Bactériologie Moléculaire, Département de recherche, Institut Pasteur du Maroc, 1 place Louis Pasteur, Casablanca-20360, Marocco.
Accepted 20 March, 2018
Abstract
Fusidic acid -resistant Staphylococcus aureus is poorly documented in community acquired infections in Morocco. From 1st January, 2007 - 31 October, 2008, we collected 140 S. aureus isolates at Institute Pasteur, Casablanca, 18 of them exhibited resistance to fusidic acid and were negative for gene encoding methicillin resistance (mecA). seh toxin gene was found in 14 strains (14/18) along with an accessory gene regulator (agr) group III, 9 of them were found with two other toxin genes (sek plus seq). In conclusion, we found a close relationship between the presence of the seh gene and the possession of agr group III in fusidic acid-resistant methicillin-sensitive S. aureus (FAR-MSSA) strains. In addition, our results indicate a relationship between 6 FAR -MSSA strains belonging to the same pulsotype and harbouring agr group III with luk -PV toxin genes.
Key words: Fusidic acid resistance, mecA gene, seh toxin gene, Staphylococcus aureus, MRSA.