ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 13 (1), pp. 001-005, January, 2019. © International Scholars Journals
Full Length Research Paper
In vitro effect of tigecycline against Mycobacterium tuberculosis and a review of the available drugs for tuberculosis
Ahmet Yilmaz Coban1*, Aydin Deveci2, Yeliz Tanriverdi Cayci1, Meltem Uzun3, Alper Akgunes4 and Belma Durupinar1
1Department of Medical Microbiology, Ondokuz Mayis University, Medical School, Samsun, Turkey.
2Ondokuz Mayis University, Medical School, Department of Infectious Diseases and Clinical Microbiology, Samsun, Turkey.
3Department of Medical Microbiology, Istanbul University, Istanbul Medical School, Istanbul, Turkey.
4Samsun Chest Diseases Hospital, Clinical Microbiology Laboratory, Samsun, Turkey.
Accepted 17 January, 2019
Abstract
The study aimed to investigate the effectiveness of a novel antibiotic drug tigecycline on clinical isolates of Mycobacterium tuberculosis and, reviewing defined anti-tuberculosis effects of available agents. Minimal inhibitory concentration (MIC) of tigecycline for 50 M. tuberculosis including multidrug-resistant (MDR) clinical isolates (20 MDR isolates) was determined by broth microdilution method in the study. Tigecycline MIC values were ranging between 8 and 64 µg/ml. However, there is not any defined break point for M. tuberculosis resistance. In conclusion, it seems that the in vitro effectiveness of tigecycline to M. tuberculosis is not good but further in vivo studies are needed.
Key words: Mycobacterium tuberculosis, tigecycline.