ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2015
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2015 International Scholars Journals
Full Length Research Paper
Effect of Helicobacter pylori infection on the lipid, lipoproteins, apolipoprotein-A1, Lipoprotein (a) and Apolipoprotein-B in patients with gastritis
Mohammad Hassan Khadem Ansari1*, Mir-davood Omrani2, Biet Sayyah1 and Sina Khadem Ansari3
1Department Clinical Biochemistry, Urmia Medical School, Urmia, Iran.
2Department of Genetic, Urmia University of Medical Sciences, Urmia, Iran.
3Medical Faculty of Osmangazi University, Turkey.
Accepted 7 October, 2014
Abstract
There are evidences of relationship between chronic infections of Helicobacter pylori (H. pylori) and gastritis in some previous studies. The gastritis caused by H. pylori leads to a change in serum levels of lipids, lipoproteins, apolipoprotein-A1 (Apo-A1), apolipoprotein- B (Apo-B) and lipoprotein- a (Lp(a)) . These changes will lead to thrombogenesis and other cardiovascular diseases. The aim of this study is to find out a correlation between lipids profiles and helicobacter gastritis. In this study 20 males and 20 females in age between 30 - 50 years old with gastritis resulting from H. pylori were chosen as patients group. Patients serum levels of Apo- A1, Apo -B and Lp(a) as well as total cholesterol, triglyceride, High density lipoprotein (HDL -C) and Low density lipoprotein (LDL-C) were measured. As control, 26 persons with other types of gastritis (helicobacter negative), without having diseases such as: diabetes, hyperlipidemia, renal failure, liver diseases, with similar age ranges were chosen. Mean levels of total Cholesterol, triglyceride, LDL-C, ApoB lipoprotein and Lp (a), as well as total Cholesterol/HDL ratio and LDL-C/HDL-C ratio in patients with gastritis resulted by H pylori were significantly increased compared to control groups. In addition HDL-C and Apo- A1 lipoprotein were decreased significantly. Therefore it was possible to conclude that H. pylori infection can cause lipid metabolism disorders that may act as risk factors for cardiovascular diseases.
Key words: Gastritis, H. Pylori, lipids, lipoprotein, Apo lipoprotein, Lp (a).