ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2016
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2016 International Scholars Journals
Full Length Research Paper
Effect of blood group and demographic characteristics on malaria infection, oxidative stress and haemoglobin levels in South Western Nigeria
O. M. Akanbi1, J. A. Badaki1, O. Y. Adeniran2 and O. O. Olotu1
1Department of Environmental Biology and Fisheries, Adekunle Ajasin University, Akungba-Akoko, Ondo state, Nigeria.
2Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo state, Nigeria.
Accepted 26 January, 2015
Abstract
Malaria infection generates oxidative stress which has serious effect on the haemoglobin (Hb) level of the infected individuals. This work studied the effect of blood group, age and gender on prevalence of malaria, oxidative stress and Hb level. 5 ml of blood samples were collected into EDTA bottle from 120 volunteered adult males and non-pregnant females. The plasma was separated and used to quantify oxidative stress by measuring malonaldehyde (MDA) and superoxide dismutase (SOD) levels using colorimetric method, while haematological parameter and malaria parasite screening was done using a whole blood. The parasite density and MDA levels were significantly higher (P < 0.05) in individuals with blood group A than those with blood group B and O. SOD and Hb levels were lower in those with blood group A than those with blood group B and O. The parasite density and MDA levels were significantly higher in age group 18 - 21 years than other age groups but SOD was higher (P < 0.05) in age group 22 - 25 and 26 - 30 than age group 18 - 21. The parasite density and MDA were higher (P < 0.05) in males than females in this study. The findings indicate that gender, sex and blood group have impact on malaria infection and oxidative stress.
Key words: Malaria, blood grouping, gender, oxidative stress, haemoglobin, age.