ISSN 2169-3048
International Journal of Biochemistry and Biotechnology ISSN 2169-3048 Vol. 6 (3), pp. 745-749, March, 2017. © International Scholars Journals
Full Length Research Paper
Influence of aging, free radicals and weight gain since menopause on bone mineral metabolism
1Ruchi Kant*, 2Navneet Kumar and 2Yirga Adugna
1Department of Chemistry, College of Natural Sciences, Wollo University, Dessie, Ethiopia.
2School of Medicine, College of Medicine & Health Sciences, Post Box-1145, Wollo University, Dessie, Ethiopia.
*Corresponding author E-mail: [email protected]
Accepted 05 September, 2016
Abstract
Bone is a dynamic tissue that is being remodel constantly throughout life. It is composed primarily of the inorganic materials (Ca and Phosphate) and organic matrix (type-1- collagen). Bone formation is an orderly process in which inorganic mineral is deposited in relation to organic matrix. During the bone resorption first calcium and phosphorus are released into the extra cellular fluids and organic matrix is then desorbed. The concentrations of Ca, Phosphate and Mg in plasma are dependent on the net effect of bone mineral deposition and resorption, then intestinal absorption and renal excretion. Osteoporosis is the term used for diseases that cause a reduction in the mass of bone per unit volume and is one of the dreaded afflictions of ageing. There is a close relationship between estrogen deprivation and its development. In the present study, we investigate the effect of age and body weight on blood indicators of bone health namely, Ca, Mg and P. Bone mineral marker ALP was used which have more advantages when predicting the postmenopausal bone loss. The subjects were classified into three groups namely controls, premenopausal and postmenopausal. In our study blood levels of both Ca as well as Mg were found to be lowered in postmenopausal women. Mg and Fe are the major minerals that doctors find deficient in people who are overweight. Blood level of P is also decline in our study. So, that Ca: P ratios are maintained.
Keywords: Menopause, oxidative stress, ageing, mineral, enzymes.