ISSN 2756-3340
African Journal of Infectious Diseases Research ISSN 4729-6836 Vol. 7 (3), pp. 001-004, March, 2020. © International Scholars Journals
Full Length Research paper
Human leukocyte antigen (HLA) Cw allele association among psoriasis patients from Western India
U. Shankarkumar*, A. Shankarkumar and K. Ghosh
National Institute of Immunohaematology, Indian Council of Medical Research 13th Floor, KEM Hospital, Parel, Mumbai – 400012, India.
Accepted 07 December, 2019
Abstract
Psoriasis a common autoimmune disorder characterized by T cell mediated keratinocyte hyperproliferation known to be associated with the presence of certain specific HLA alleles. In this study our aim was to evaluate distribution of Human leukocyte antigen (HLA-Cw) susceptible allele of psoriasis from patients in Western India. The study included 84 Psoriasis patients and 91 normal individuals from the same geographical region. Human leukocyte antigen HLA-C was typed using high resolution polymerase chain reaction- sequence specific oligonucleotide probes (PCR-SSOP) technique. The study revealed significant increase in frequencies of Cw*0202 (OR-6.508, P<0.0001) and Cw*0604 (OR-17.710, P=0.0153) when compared to controls while Cw*1502 (OR-0.130, P=0.0490) were significantly decreased in psoriasis patients. Our study shows a strong association of HLA Cw*0202 and Cw*0604 alleles with psoriasis conferring to its susceptibility to psoriasis patients from Western India.
Key words: HLA Cw alleles, Psoriasis, Mumbai, Western India.