ISSN 2167-0404
International Journal of Medicine and Medical Sciences ISSN 2167-0404 Vol. 10 (4), pp. 001-007, April, 2020. © International Scholars Journals
Full Length Research Paper
Evaluation of anti-ulcer, anti-secretory and anti-helicobacter pylori effects of folkloric medicinal plant, Fumaria vaillantii L, in rats
Ali Z.A,* Bhutto M.A and Zulfiqar J.P
Department of Pharmacognosy, Faculty of Medicinal Plants and Alternative Medicine, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.
Accepted 03 January, 2020
Abstract
This paper evaluated anti-ulcer, anti-secretory and anti-helicobacter pylori effects of folkloric medicinal plant, Fumaria vaillantii L, in rats. Different toxic agents; ethanol (80%), NaOH (0.2 mol/L), NaCl (25%) and indomethacin (30 mg/kg, body weight) were used to produce acute gastric ulceration in rats. Anti-secretory studies were undertaken by using pylorus-ligation, Shay rat technique. F. vaillantii L aqueous extract (Aq-FV) was used in three doses (100, 200 and 300 mg/kg bodyweight). Aq-FV was further tested for anti-H. pylori activity. Extract significantly attenuated gastric mucosal damage induced by toxic agents and indomethacin in rats. Aq-FV restored partially mucus secretion in indomethacin model. In pylorus-ligated rats, Aq-FV significantly reduced the basal gastric acid secretion, acidity and ulceration. Aq-FV possesses significant and more potent anti- ulcer and cytoprotective activities against experimentally-induced gastric ulcers in comparison to Omeprazole. Extract showed significant but less potent anti-H. pylori activity in comparison to Clarithromycin. Evaluation agreed with the folkloric use of F. vaillantii L as anti-ulcer and anti-secretory tool.
Key words: Fumaria vaillantii L, cytoprotection, gastric ulcer, gastric secretion, gastric wall mucus, anti-helicobacter pylori.