ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2736-1756 Vol. 14 (7), pp. 001-005, July, 2020. © International Scholars Journals
Full Length Research Paper
Distribution of sulfamethoxazole trimethoprim constin in Vibrio cholerae isolated from patients and environment in Iran
Maryam Adabi1,2, Mosadegh Jabbari3 and Abdolaziz Rastegar Lari1*
1Anti-microbial Resistant Research Center. Tehran University of Medical Science, Tehran, Iran.
2Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
3Rasool-E-Akram hospital, Tehran University of Medical Sciences, Tehran Iran.
Accepted 21 May, 2020
Abstract
The occurrence of drug-resistant Vibrio cholerae is being reported with increasing frequency worldwide. Spread of resistant strains has been attributed, in part, sulfamethoxazole trimethoprim-constin (SXT-C). Sixty V. cholerae isolates obtained from cholera patients from different provinces in Iran during 2004 to 2006 and thirty-seven V. cholerae strains from surface water sources at 5 different locations in Tehran, Iran during 2006 were subjected to antibiotic susceptibility testing and polymerase chain reaction amplification of SXT-C. In clinical isolates the highest and the least levels of antibiotic resistance were seen to SXT, streptomycin and chloramphenicol (95, 95 and 92%, respectively) and doxycycline, gentamicin and oxytetracycline (0, 3 and 3%, respectively). PCR for SXT element of clinical and environmental isolates was positive for 95 and 19% of isolates, respectively. The results of this study showed that among the clinical and environmental V. cholerae resistance to SXT, streptomycin and chloramphenicol could be, in part, due to wide distribution of SXT-C isolates.
Key words: Anti-microbial resistant, Vibrio cholerae, sulfamethoxazole trimethoprim-constin (SXT-C).