African Journal of Parasitology Research

African Journal of Parasitology Research ISSN 2756-3391 Vol. 11 (1), pp. 001-004, January, 2023. © International Scholars Journals

Full Length Research Paper

Clostridium difficile infection- an overview on recurrences over two years

Alexandra Lacatusu^1*, Ioana Iordan¹, Carmen Manciuc^1,2

¹Sf. Parascheva” Infectious Diseases Hospital Iasi, Romania.

²Grigore T. Popa ”University of Medicine and Pharmacy Iasi, Romania.

Accepted 20 November, 2022

Abstract

Introduction: Clostridium difficile infection (CDI) is the leading infectious cause of antibiotic-associated diarrhea. The annual rate of the recurrences can be over 100.000 cases and the costs per episode can be over 10.000 euros. Despite the prevention programs implemented in many countries, the rate of the infection continues to increase Purpose: The aim of the study was to evaluate the rate of recurrence of CDI in the patients admitted in “Sf Parascheva” Infectious Diseases Hospital from Iasi, Romania over a period of 2 years (January 1^st 2017 to December 31^st 2018). Results: Of all the patients addmited in our hospital for CDI in 2017 and 2018, 30,56% were hospitalized for the recurrence of the infection. After analyzing the number of recurrence of the infection 64,89 % of the patients were at the first recurrence, over 19% had a second recurrence of the CDI and the rest, had a 3^rd to 6^th recurrence. Conclusion: CDI is still a big problem that causes a major burden on the healthcare system and also on the patient. Over 65% of the patients included in the study presented for the first recurrence of CDI, and the rest for second to sixth episode.

Keywords: Clostridium difficile infection, recurrence, treatment