ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2017
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2017 International Scholars Journals
Full Length Research Paper
Correlation analysis of inhibin B, follistatin and activin A in patients with polycystic ovary syndrome
Shen ZongJi1, Chen Xiao-Ping2*, Wang WanXiang3, Liu HongMei2 and Ren XinPing2
1Department of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou 215006, China.
2Department of Obstetrics and Gynecology, YanCheng 1st People Hospital, YanCheng City 224000 Jiangsu, China.
3Clinical laboratory, YanCheng 1st People Hospital, YanCheng City 224000 Jiangsu, China.
Accepted 17 May, 2016
Abstract
Polycystic ovarian syndrome is a term used to describe women who have a tendency, because of abnormal ovulation to develop multiple small cysts on their ovaries. In this study, we investigated the abnormal levels of serum inhibin B, follistatin and activin A in patients with polycystic ovary syndrome (PCOS). Serum levels of inhibin B, follistatin and activin A on cycle day 3 were measured both in PCOS group and in controls (women with regular cycle). The difference between the two groups and relationship of inhibin B, follistatin and activin A with other sex hormone, body mass index (BMI), insulin and fast glucose were analyzed. Levels of serum inhibin B in PCOS were higher (P < 0.001) (290 ± 86 pg/ml) than those of controls (172 ± 53 pg/ml) and follistatin were higher (P = 0.01) in PCOS (1317 ± 392) pg/ml than controls (804 ± 203) pg/ml. Levels of serum activin A were lower (P < 0.05) in PCOS (545 ± 44 pg/ml) than those of controls (588 ± 89 pg/ml). In PCOS women, serum inhibin B levels were positively correlated with insulin (r = 0.436, P < 0.05) and glucose (r = 0.618, P < 0.05). Serum activin A levels were negatively correlated with insulin (r = -0.442, P < 0.05). Serum follistatin levels were positively correlated with age and negatively correlated with T. Abnormal paracrine or autocrine in inhibin/follistatin/activin system may be partly responsible for the hypogenesis of pre-ovular follicles in PCOS and it is obvious that hyperinsulinemia may be affected by higher concentrations of inhibin B and lower concentrations of activin A.
Key words: Polycystic ovary syndrome, follistatin, activin, hyperinsulinemia.