ISSN 2169-3048
International Journal of Biochemistry and Biotechnology ISSN: 2167-0404 Vol. 2 (6), pp. 457-460, 2013. © International Scholars Journals
Full Length Research Paper
Hypoglycemic Effect of Ethanol Extract and Fractions of Nauclea latifolium leaf on normal and alloxan-induced diabetic rats
Asanga E. Effiong1, Patrick Ebong1, Olorunfemi A. Eseyin2*
1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Nigeria.
2Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmacy, University of Uyo, Nigeria.
*Corresponding author: [email protected]
Accepted 20 July, 2012
Abstract
The hypoglycemic effect of ethanol extract and fractions of Nauclea latifolium leaf was evaluated in this study. The result in normoglycemic rats showed maxima glycemic reduction of 26.4% within 4 hours in the group treated with butanol fraction (250 mg/kg) which proved efficacious than glibenclamide at p < 0.05. Also, similar advantage over glibenclamide was recorded in ethanol extract (250 mg/kg) given alloxan-induced diabetic rats with % glycemic change of 44.4% as compared to 32.2% of glibenclamide within 4 hours n-hexane fraction (100 mg/kg) and butanol fraction (250/kg) recorded maxima % glycemic changes of 73.2% and 71.2%, respectively, within a period of 14 days at p < 0.05 in alloxan-induced diabetic rats. These findings suggest that ethanol extract and fractions of Nauclea latifolium leaves possess hypoglycemic.
Key Words: Hypoglycaemic, nauclea latifolium, alloxan-induced diabetes.