International Journal of Medicine and Medical Sciences

ISSN 2167-0404

International Journal of Medicine and Medical Sciences ISSN 2167-0404  Vol. 10 (2), pp. 001-005, February, 2020. © International Scholars Journals

Full Length Research Paper

A study on the determinants of the effects of Aloe vera on indomethacin induced ulcers in rats

Borris N.K*, Arriel J.S and Roa B.S

Department of Pharmacy, Faculty of Medical Sciences, Guru Gobind Singh Indraprastha University, Delhi, India.

Accepted 13 July, 2019

Abstract

This study was performed to determine the effects of Aloe vera on indomethacin induced ulcers in rats. Albino rats (Wister strain) of either sex weighing between 150 and 200 gms were randomly allotted into four groups with six animals each. Indomethacin was administered orally in the dose of 20 mg/kg body weight and kept fasting for 6 h. A. vera powder was mixed with gum acacia, the solution was administered orally through the oral gavage to rats in the dose of 200 mg/kg. Omeprazole (20 mg/kg) was administered intraperitoneally as a standard drug for present study. At the end of the study, rats were sacrificed and stomachs were opened and stored in 5% formalin solution, ulcer index and histological changes were studied. Student-‘t’ test analysis was used for the present study. It was found that A. vera showed statistically significant anti-ulcer activity comparable to standard drug omeprazole. The mean ulcer indexes of two drugs were statistically significant (P value is < 0.001). Therefore, the results were suggestive of anti ulcerogenic activity of A. vera.

Key words: Aloe vera, gastric ulcer, indomethacin, omeprazole.