ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 12 (8), pp. 001-005, August, 2018. © International Scholars Journals
Full Length Research Paper
Antimicrobial agents from the leaf of Struchium sparganophora (Linn) Ktze, Asteraceae
L.S. Kasim1*, V.A. Ferro2, O.A. Odukoya3, Allan Drummond4, G.E. Ukpo3, Veronique Seidel4, A. I. Gray4 and Roger Waigh4.
1Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
2Department of Immunology, University of Strathclyde, Glasgow, G4 0NR, UK.
3Faculty of Pharmacy. University of Lagos, Idi- Araba, Lagos. Nigeria.
4Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, G4 0NR UK.
Accepted 4 July, 2018
Abstract
Three Antimicrobial agents from the leaf of Struchium sparganophora were isolated by chromatographic methods and characterized. The microbial inhibitory activity of these compounds was investigated against Gram-positive, Gram-negative bacteria and fungi. The antimicrobial activity of some of these compounds was similar in some of the micro-organisms used for the tests except Klebsiella. aerogenes and the fungus Candida albicans where all the compounds showed minimum inhibitory concentration (MIC) values between 50 and 6.25 µg/ml. Luteolin and 3 methyl 2, 6, hexacosedienol significantly inhibited the growth of the two fungi (P<0.05) while vernodalin did not show strong activity against Aspergillus niger with MIC of 100 ug/ml. These compounds contribute to the anti-infective use of this plant in folkloric medicine and also these compounds could be used as natural antimicrobial agents in the food preservation and human health.
Key words. Struchium sparganophora, antimicrobial, luteolin, vernodalin, 3 methyl, 2, 6 hexacosedienol.