Advanced Journal of Microbiology Research

Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 13 (3), pp. 001-004, March, 2019. © International Scholars Journals

Full Length Research Paper

Antibacterial and cytotoxic activity of Eremurus persicus (Jaub and Spach) Boiss

Mojdeh Hakemi Vala¹, Jinous Asgarpanah²*, Mohammad Hossein Hedayati³, Jeilan Shirali² and Fatemeh Bagheri Bejestani⁴

¹Microbiology Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

²Pharmacognosy Department, Pharmaceutical Sciences Branch and Pharmaceutical Sciences Research Center, Islamic Azad University (IAU), Tehran, Iran.

³Pasteur Institute of Iran (Karaj branch), Iran.

⁴Microbiology Department, Pharmaceutical Sciences Branch, Islamic Azad University (IAU), Tehran, Iran.

Accepted 10 January, 2019

Abstract

Traditional medicine has a key role in health care worldwide. Obtaining scientific information about the efficacy and safety of the plants is one of the researcher's goals. In this research, the flowering aerial parts of Eremurus persicus were collected from Golpayegan (Isfahan, Iran) in May 2010. The extract was tested for its antibacterial activity against 4 Gram- positive bacteria strains (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus cereus, Streptococcus pyogenes) and 5 Gram-negative bacterial strains (Escherichia coli, Salmonella typhi, Shigella dysantriae, Klebsiella pneumoniae, Pseudomonas aeruginosa). Its cytotoxic activity was also investigated using MTT assay. Here we reported the antibacterial activity of E. persicus against S. aureus (MIC = 125 mg/ml), B. cereus (MIC = 15.62 mg/ml), E. coli (MIC = 125 mg/ml), S. typhi (MIC = 31.25 mg/ml), S. dysantriae (MIC = 0.48 mg/ml) for the first time. Furthermore the cytotoxic potentials of E. persicus on two cell lines, HeLa and Caco-2, were studied.

Key words: Eremurus persicus, antibacterial activity, cytotoxic activity.