ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2015
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2015 International Scholars Journals
Full Length Research Paper
Association of IGF- 1 gene polymorphism with milk production traits and paternal genetic trends in Iranian Holstein bulls
Yousef Mehmannavaz1*, Cyrus Amirinia2, Mortaza Bonyadi3 and Rasoul Vaez Torshizi4
1Department of Animal Science, Faculty of Agriculture, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2Department of Animal Biotechnology, Animal Science Research Institute of Iran, Karaj, Iran.
3Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran.
4Animal Science Department, Faculty of Agricultural, Tarbiat Modares University, Tehran, Iran.
Accepted 12 November, 2014
Abstract
The effects of Insulin-Like Growth Factor-1 polymorphism were examined on milk production traits and genetic trends in the Iranian Holstein bulls. A total of 282 bulls were genotyped for SnaBI restriction site in the 5' flanking region of IGF-1 by applying PCR-RFLP method. The allele frequencies for C and T alleles were 0.562 and 0.438, respectively. The results indicated that genetic variants at the 5'-noncoding region of the bovine IGF-1 gene had a marked effect on estimated breeding values of milk (EBVM) and fat yields (EBVF). The heterozygous bulls (CT genotype) had higher EBVM and EBVF than homozygous bulls (P < 0.1) . The average substitution effects of alleles were not significant for none of studied traits (P > 0.1). The studied polymorphism of IGF-1 showed no significant association with genetic trends of milk related traits (P > 0.1). These results suggest that allelic interaction in IGF-1 polymorphism as over dominance and might be effectiveness in animal improving by crossbreeding.
Key words: IGF-1, polymorphism, Holstein, genetic trend.