ISSN 2167-0404
International Journal of Medicine and Medical Sciences ISSN: 2167-0404 Vol. 2 (12), pp. 278-283, December, 2012. © International Scholars Journals
Case report
Complete response of liver metastatic gastric cancer after FOLFOX-4 chemotherapy regimen followed by salvage gastrectomy: A case report
Bandhuphat Chakrabandhu1*, Sirikan Yamada1, ShunJi Kato2, Nobutoshi Hagiwara2 and Thiraphat Chakrabandhu1
1Chiang Mai University, Chiang Mai, Thailand
2Nippon Medical School, Tokyo, Japan
*Corresponding author. E-mail: [email protected]
Received 05 August, 2012; Accepted 12 December, 2012
Abstract
A 48-year-old Thai male with metastatic liver gastric adenocarcinoma achieved a complete pathological response after neoadjuvant chemotherapy. The patient underwent a esophagogastroduodenoscopy in October, 2008, which revealed a ten centimeter ulcerated tumor mass at his antrum with complete gastric outlet obstruction. The biopsy of his gastric ulcer showed high grade necrotic adenocarcinoma. Further workups with computed tomography staged his cancer as cT4bN1M1 P0 CYX H1. He received 12 cycles of neoadjuvant chemotherapy consisting of oxaliplatin and fluoropyrimidine. The follow up computerized tomography CT scan, showed a complete regression of liver metastasis. Afterwards, he underwent a subtotal gastrectomy with D2 lymph node dissection showing a complete pathological response (grade 3 according to Japanese Classification of Gastric Carcinoma 3rd English edition). Postoperatively, he received eight cycles of capecitabine. After a 43 month follow up period, there is no recurrent disease.
Key words: Gastric cancer, salvage operation, chemotherapy, metastasis, FOLFOX-4, capecitabine.