ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 13 (4), pp. 001-005, April, 2019. © International Scholars Journals
Review
New chimeric anti-tubercular dendrimers with self-delivering property
Ghazaleh Ghavami and Soroush Sardari*
Drug Design and Bioinformatics Unit, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute, #69 Pasteur Ave., Tehran 13164, Iran.
Accepted 15 February, 2019
Abstract
Tuberculosis is the second lethal infectious disease caused by Mycobacterium species. This pathogens could cause severe disease like tuberculosis and leprosy in human. Today there are a number of anti tuberculosis agents utilized in treatment of this disease but multiple drug resistance is one of the major problems that end to failure in treatment. Dendrimers are synthetic, high branched polymers with a number of functional groups that could bind to different macromolecules like drugs, oligosaccharides that makes it appropriate for target drug delivery. Today, some type of dendrimers like Jeffamines are developed possessing self antimicrobial activity. Hypothesis: we propose that combination of ethambutol with 3rd generation of Jeffamine core based dendrimer (P3) and mannose could both create a complex compound with high potency against mycobacterium species that is targeted to macrophages via interaction between lectin receptors on immune cells and mannose molecules on outer branch of P3.
Key words: Tuberculosis, dendrimers, Jeffamines, Mycobacterium, ethambutol