Advanced Journal of Microbiology Research

Advanced Journal of Microbiology Research Vol. 2017

Available online at http://internationalscholarsjournals.org/journal/ajmr

© 2017 International Scholars Journals

Full Length Research Paper

Prevalence and characterization of extended-spectrum beta-lactamase production in clinical isolates of Klebsiella spp.

Rashid Ramazanzadeh

Microbiology Department, Faculty of Medicine, Kurdistan University of Medical Science, Sanandaj, Iran. E-mail: [email protected] or [email protected].

Accepted 20 January, 2017

Abstract

Extended-spectrum beta-lactamases (ESBLs) are most prevalent in Klebsiella pneumoniae. This organism is frequently isolated from clinical specimens and can cause septicemia, pneumonia or urinary tract infection. We investigated a spread of Klebsiella spp. isolates producing ESBL in a university hospital of Sanandaj- Iran. Over one year period, a total of 48 K. pneumoniae isolates, were examined by double disk tests and PCR methods. Ten isolates were defined as ESBLs. The ESBL producer isolates was more resistant to selected antibiotics than ESBL negative isolates. The most frequent ESBL type was CTX-M. This is the first report of Klebsiella spp. isolates producing ESBL in Sanandaj hospitals. Production of ESBLs by K. pneumoniae is a widespread nosocomial problem. Knowledge about their prevalence is essential to guide towards appropriate infection control and antibiotic management strategies.

Key words: Extended-spectrum    -lactamase (ESBL), hospital, Klebsiella spp.