ISSN 2756-3707
International Journal of Histology and Cytology ISSN 2447-9535 Vol. 6 (1), pp. 001-004, January, 2019. © International Scholars Journals
Review
The cellular receptors for infectious bursal disease virus
L. Q. Zhu 1, S. L. Wu1, G. P. Zhang2 and G. Q Zhu1*
1College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China.
2Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Science, Zhengzhou 450002, China.
Accepted 21 December, 2018
Abstract
Virus receptors are simplistically defined as cell surface molecules that mediate binding (attachment, adsorption) and/or trigger membrane fusion or entry through other processes. Infectious bursal disease virus (IBDV) entry into host cells occurs by recognition of specific cellular receptor(s) with viral envelope glycoprotein, which comprises the initial and key step of infection. Infection can be inhibited by blockage of the process. So the interest in receptors has been stimulated in large part by the potential in the application of developing substances that show directed blocking activity. While for the purpose one should know which host cell and viral molecules are involved in the reciprocal recognition and interaction leading to the virus entry into the cell. Here, the review presents the currently available knowledge regarding the receptors or molecules that interact with IBDV.
Key words: IBDV, SIgM, cellular receptor, chicken heat shock protein 90α.