ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2016
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2016 International Scholars Journals
Full length Research Paper
Demineralized bone matrix gelatin as scaffold for tissue engineering
Yong Pan1, Shiwu Dong2, Yong Hao1, Tongwei Chu1, Changqing Li1, Zhengfeng Zhang1 and Yue Zhou1*
1Department of Orthopaedics, Xinqiao Hospital, the Third Military Medical University, Chongqing, 400037, China.
2Department of Anatomy, College of Basic Medicine, the Third Military Medical University, Chongqing, 400038, China.
Accepted 28 April, 2016
Abstract
The aim of the present study was to do a comparative light microscopical and histochemical analysis of bone regeneration processes in rabbits, with the use of demineralized bone matrix gelatin scaffolds. Our histological results showed that no gelatin scaffold was extruded, indicating that neither body fluid nor blood swept the gelatin scaffold from the implantation site, nor was the gelatin scaffold biodegraded. Additionally, no abscess or inflammation of the peripheral osseous tissues at the implantation site was observed, suggesting that the implantation of the gelatin scaffold in the vertebra bone defect did not cause histopathology or exhibit malbiocompatibility with the peripheral osseous tissues.
Key word: Demineralized bone matrix gelatin scaffolds, tissue engineering.