ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 14 (9), pp. 001-006, September, 2020. © International Scholars Journals
Full Length Research Paper
Red blood cell membrane stabilizing potentials of extracts of Lantana camara and its fractions
O. O. Oyedapo*, B. A. Akinpelu, K. F. Akinwunmi, M. O. Adeyinka and F. O. Sipeolu
Department of Biochemistry, Faculty of Science, Obafemi Awolowo University, Ile - Ife, Nigeria.
Accepted 23 July, 2020
Abstract
Anti-inflammatory activity of extract of Lantana camara, Linn and its fractions was investigated using stabilization of red blood cell membrane lysing technique. Phytochemically, whole plant extract (WPE) and ethanol fraction (EF) gave positive reactions for the presence of saponins, tannins, flavonoids and cardiac glycosides. The ethyl acetate fraction (EAF) gave reactions for the presence of flavonoids while butanol fraction (BF) gave positive test for the presence of saponins. The percentage membrane stability exhibited by the extract and various fractions was concentration dependent and compared favorably with those of standard drugs (Ibuprofen and Indomethacin). The results revealed that both ethanol and ethyl acetate fractions contained principles that protected the erythrocyte membranes effectively. Moreover, ethyl acetate fraction provided highest protection against induced lyses and exhibited both monophasic and biphasic responses at all the concentrations assayed. The possible mechanism of action of the extract and fractions is described and discussed.
Key words: Membrane, stabilization, anti- inflammatory, Lantana camara.