ISSN 2756-3340
African Journal of Infectious Diseases Research ISSN 4729-6836 Vol. 7 (3), pp. 001-003, March, 2020. © International Scholars Journals
Case Report
Methotrexate-induced toxic epidermal necrolysis: A case report
I. Tazi*, A. Madani, S. Zafad, M. Harif, A. Quessar and S. Benchekroun
Hematology and Pediatric Oncology, Hopital 20 Aout 1953 Casablanca Morocco.
Accepted 17 March, 2019
Abstract
Methotrexate (MTX) is a folic acid antagonist that inhibits the enzyme dihydrofolate reductase resulting in decreased cell levels of tetrahydrofolate. Adverse cutaneous reactions to MTX are usually dose-related and have been mainly reported in patients receiving extremely large doses of chemotherapy. Toxicity can affect multiple organ systems including bone marrow, liver, intestinal tract, kidneys, lungs, skin, and blood vessels, resulting in death in severe cases. In this report we describe the case of a 9 year old boy who developed toxic epidermal necrolysis after high-dose MTX treatment and discuss the important clinical and therapeutic features of this condition.
Key words: Methotrexate, skin, toxicity, necrolysis.