ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2017
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2017 International Scholars Journals
Full Length Research Paper
Efficacy of Dissotis rotundifolia on Trypanosoma brucei brucei infection in rats
Abdullahi Mann1*, Evans C. Egwim2, Barnabas Banji1, Nda-Umar Abdukadir1, Mohammed Gbate1, J. T. Ekanem3
1Department of Science Laboratory Technology, Federal Polytechnic Bida, P. M. B. 55, Bida, Niger State, Nigeria.
2Department of Biochemistry, Federal University of Technology Minna, P. M. B. 65, Minna Niger State Nigeria.
3Department of Biochemistry, University of Ilorin, P. M. B. 1515, Ilorin, Kwara State Nigeria.
Accepted 19 June, 2017
Abstract
The therapeutic potential of the crude extract of Dissotis rotundifolia was investigated in rats infected with Trypanosoma b. brucei. Animals were treated orally or intraperitoneally at 200, 600 and 800 mg/kg body weight. At 800 mg/kg, parasitemia was reduced by 66.7 and 78.4% after oral and intraperitoneal administration respectively. In vitro exposure of blood forms to high concentration (800 mg/kg) crude extract test resulted in complete paralysis or killing within 45 s of exposure. It is concluded that D. rotundifolia may contain antitrypanosomal constituents.
Key words: Efficacy, trypanosoma, parasitemia, Dissotis rotundifolia, antitrypanosomal activity.