ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2017
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2017 International Scholars Journals
Short Communication
A taurine phenolic compound (TPC) protect from AAP hepatotoxicity through involvement of Nrf2/ARE pathway
Qiu Feng* and He Xiao-Jing
Department of Pharmacy, Sheng jing Hospital of China Medical University, Shenyang 110004, People’s Republic of China.
Accepted 16 June, 2016
Abstract
Oxidative stress is a main contributor to the hepatotoxic effects of acetaminophen, the Nrf2/ARE pathway has been characterized as an important endogenous mechanism for combating oxidative stress. Taurine plays various important roles in a large number of physiological and pathological conditions in human body, such as the antioxidant, anti-inflammatory effects. It proves that phenol compound has antioxidant effect through involvement of Nrf2/ARE pathway. The taurine phenolic compound (TPC) we synthesized belongs to phenolic compounds and we have reported that a TPC protect from AAP hepatotoxicity. We thus hypothesize the protective effects of TPC in an acute chemical model of acetaminophen-induced hepatotoxicity through involvement of Nrf2/ARE pathway.
Key words: TPC, AAp, hepatotoxicity, Nrf2/ARE and hypothesis.