ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2015
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2015 International Scholars Journals
Full Length Research Paper
Antiviral effect of Hibiscus sabdariffa and Celosia argentea on measles virus
Omilabu A. Sunday1*, A. Bankole Munir5, O. Oyefolu Akeeb3, A. Adesanya Bolanle2 and S. O. Badaru4
1Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Akoka, Lagos, Nigeria.
2Department of Botany and Microbiology, University of Lagos, Akoka, Lagos, Nigeria.
3Department of Microbiology, Lagos State University, Ojo, Lagos, Nigeria.
4Central Public Laboratory, Ministry of Health, Yaba, Lagos, Nigeria.
5Ministry of Health Lagos State, Ikeja, Lagos, Nigeria.
Accepted 17 December, 2014
Abstract
Studies on extracts and biologically active compounds isolated from medicinal plants have doubled in the last two decades. The leaves of Hibiscus sabdariffa (red and green leaved) and Celosia argentea were studied for their antiviral activities against Measles Virus (MV) as well as the effects of the extracts on Hep -2 cells. Ethanol extract of the leaves of each of these plants showed no toxicity to the Hep-2 cells at all concentrations used (5, 10 and 15 mg/ml). The pre-inoculative treatment of Hep-2 cells with plant extracts showed that C. argentea had no antiviral activities on MV at all concentrations (5, 10, 15 mg/ml) while H. sabdariffa had antiviral activities only at 10 and 15 mg/ml on MV. The post-inoculative treatment of Hep-2 cells with plant extracts showed that at 5, 10 and 15 mg/ml concentrations, H. sabdariffa had antiviral activities on MV while the antiviral activity of C. argentea could not be established at 10 and 15 mg/ml but did not show any antiviral activity at 5 mg/ml.
Key words: Hibiscus sabdariffa, Celosia argentea, antiviral, toxic, Hep-2 cell, herb, medicinal plant.