ISSN 2736-1756
Advanced Journal of Microbiology Research ISSN 2241-9837 Vol. 13 (2), pp. 001-003, February, 2019. © International Scholars Journals
Short Communication
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit growth of yeast pathogens
Desmond M. Ncango1, Carolina H. Pohl1, Pieter W. J. van Wyk2 and Johan L. F. Kock1*
1UNESCO MIRCEN, Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, P. O. Box 339, Bloemfontein, 9301, South Africa.
2Centre for Microscopy, University of the Free State, P. O. Box 339, Bloemfontein, 9301, South Africa.
Accepted 10 January, 2019
Abstract
Studies on yeasts exposed non-steroidal anti-inflammatory drugs (NSAIDs) such as acetylsalicylic acid (aspirin) as potential anti-mitochondrial antifungals. In this study, various NSAIDs were tested for antifungal activity on the human yeast pathogens Candida albicans and Cryptococcus neoformans. Our results suggest a dual action for these drugs, that is, antifungal as well as anti-inflammatory. These results could be useful in the treatment of fungal infections.
Key words: Acetylsalicylic acid, antifungal, anti-inflammatory drugs, anti-mitochondrial, Candida albicans, Cryptococcus neoformans, Eremothecium ashbyi.