ISSN 2736-1756
Advanced Journal of Microbiology Research Vol. 2016
Available online at http://internationalscholarsjournals.org/journal/ajmr
© 2016 International Scholars Journals
Full Length Research Paper
Evaluation of salivary gland scintigraphy, magnetic resonance and diffusion-weighted imaging in clinical diagnosis of Sjögren’s Syndrome
Mei Li1, Hao-Jie Dai1, Zhen-Chang Wang2*, Zhen-Gang Wang3, Li Cui3, Qing-Gang Xu2 and Jing Li2
1Department of Nuclear Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
2Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
3Department of Rheumatism, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Accepted 15 March, 2015
Abstract
To assess diagnostic effectiveness of Sjögren’s syndrome (SS), salivary gland scintigraphy (SGS), magnetic resonance (MR) and diffusion-weighted imaging (DWI) were performed in 54 patients (primary SS, secondary SS and connective tissue disease (CTD) but without SS). Results showed that SGS and diffusion-weighted magnetic resonance imaging (MRI) provided high-resolution images of the parotid glands that enabled apparent diffusion coefficient (ADC) measurements. After overall analysis, all of the oral activity indices, the maximum accumulation (MA) and uptake rate (UR) of the parotid gland clearly decreased as clinical severity progressed, and statistically significant differences were observed. Our technique may prove helpful in diagnosing the progression of SS beyond its early stages.
Key words: Diffusion-weighted imaging, salivary gland scintigraphy, Sjögren’s syndrome, receiver operating characteristic curve.