ISSN 2756-3707
International Journal of Histology and Cytology ISSN 2756-3707 Vol. 7 (7), pp. 001-006, July, 2020. © International Scholars Journals
Full Length Research Paper
Effect of LAWSONIA INERMIS treatment on mice with sarcoma
Mehmet Emin Zumrutdal1, Mehmet Ozaslan2*, Mehmet Tuzcu3, Mehmet Emin Kalender5, Kenan Daglıoglu4, Atilla Akova1, Isık Didem Karagöz2, Đbrahim Halil Kilic2, Omer Colak5 and Fatih Köksal7
1Departmant of General Surgery, Numune Training Hospital, Adana/Turkey.
2Departmant of Biology, University of Gaziantep, 27310 Gaziantep/Turkey.
3Veterinary Research Institute, 01330 Adana/Turkey.
4Animal Research and Đmplementation Center, 01330 Adana/Turkey.
5Departmant of Oncology, Faculty of Medicine, Gaziantep/Turkey.
6Deparment of Biology, University of Cukurova, 01330 Adana/Turkey.
7Deparment of Microbiology, University of Cukurova, 01330 Adana/Turkey.
Accepted 12 April, 2020
Abstract
LAWSONIA INERMIS commonly is used as cosmetic material. However many studies had shown that L. INERMIS had antitumoural, antimicrobial and anti-tuberculostatic effects. The aim of this study was to investigate whether L. INERMIS can destroy cancer cells by induction of apoptosis due to decreasing of intracellular H+ ion level or increasing intracellular free radicals and H2O2 levels in cancer cells as a result of oxidative effect or not. We used 70 female Swiss albino mice and divided them into four groups. Group 1 was given only tap water. Group 2 was given only L. INERMIS. Group 3 was given Ehrlich ascites tumour (EAT) cells + tap water and Group 4 was given EAT + L. INERMIS. At the result of this study the thickness of subcutaneous lipid tissue, diameters of gluteal mass, the pH levels of gluteal mass, the GSH levels at the liver tissue samples and the MDA levels of the liver tissue samples of these groups were measured. This study showed that, L. INERMIS can be used as a supplementary agent for cancer treatment.
Key words: L. inermis, Ehrlich ascites tumour, Ehrlich ascites carcinoma, antitumoral.