ISSN 2326-7275
International Journal of Anatomy and Physiology ISSN: 2326-7275 Vol. 7 (9), pp. 001-005, September, 2018. © International Scholars Journals
Full Length Research Paper
Pharmacological studies of some pyrimidino derivatives
Saleh A. Bahashwan
College of Health Sciences, Pharmacy Department, Taibah University, Medina Munawarah, Saudi Arabia. E-mail: [email protected]. Tel: +966505308524. Fax: +9668450144.
Accepted 07 April, 2018
Abstract
Pyrimidine derivatives, in general, have received significant interest due to their purported biological activities the anti-inflammatory, analgesic, anti-Parkinsonism, and anti-microbial activities for five 2[(N-methyl indolyl)-methyl] pyrimidino derivatives 1-5 is reported. Pharmacological screenings showed that these compounds have good anti-inflammatory, analgesic, anti-Parkinsonism, and anti-microbial activities comparable with reference drugs. Compound 2 showed similar activity of diclofenac sodium as analgesic. Compound 1, 2, 4 and flurbiprofen exhibited essentially equipotent anti-inflammatory activities. Compounds 1 and 3 were the most potent anti-Parkinsonism agents compared with benztropine. In addition, compounds 1-5 showed antimicrobial activities comparable to streptomycin, erythromycin and fusidic acid as reference drugs. These pharmacological studies provide the activities for new pyrimidino derivatives and are expected to possess notable chemical and pharmacological activities for further pharmacological research.
Key words: Pyrimidino, pharmacological, analgesic, anti-inflammatory, anti-Parkinsonism.