African Journal of Parasitology Research

African Journal of Parasitological Research Vol. 1 (3), pp. 028-034, November, 2014. © International Scholars Journals

Full Length Research Paper

Parasitological assessment of potential competitor immunizations in Schistosoma mansoni-contaminated mice

^*1Abdamelek Ramzy, Al-Shennawi Elwi¹ and Shwikar Mourad²

¹Department of Clinical Pathology, Faculty of Medicine, Cairo University, Giza, Egypt.

²Department of Medical Parasitology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

E-mail: [email protected]

Accepted 15 October, 2014

Abstract

This study expects to evaluate the prophylaxis of diverse single and joined unrefined antigens utilized as hopeful antibodies as a part of a test model of Schistosoma mansoni contamination. Cercarial antigen planning (CAP), solvent worm antigen readiness (SWAP), dissolvable egg antigen (SEA) and joined antigens (CAP + SWAP + SEA) against schistosomiasis consolidated with either Freund's adjuvant or with Bacillus Calmette-Guérin (BCG) were tried for antibody adequacy in Albino mice by catching their consequences for worm load and tissue egg number (liver and digestive system). The information acquired demonstrated that, the consolidated antigens was the most defensive with huge decrease in the worm trouble (90.28%), and tissue egg load (liver and digestive system: 93.67 and 93.98%), separately. Accordingly, consolidating these diverse antigens (CAP, SWAP and SEA) gives enlargement of the defensive safety contrasted with every segment managed separately. The mix in this manner emerges as a potential competitor worth considering in the advancement of an attainable immunization against schistosomiasis

Key words: Schistosoma mansoni, vaccine, egg count, worm burden, contamination, prophylaxis.