ISSN 2326-7267
International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 14 (2), pp. 001-005, February, 2025. Available online at www.internationalscholarsjournals.org © International Scholars Journals
Full Length Research Paper
Comparative Analysis of Aggressive vs. Conventional Atorvastatin Doses on IL-6 and NO Levels in Acute Myocardial Infarction Patients
Mustafa Kemal BASARALI1, Sadık BUYUKBAS1, Hayrullah YAZAR2*, Aysel KIYICI3, Mehmet KAYRAK4 and Sıddık ULGEN5
1Department of Biochemistry, Medical Faculty, Dicle University, Diyarbakır, Turkey.
2Department of Biochemistry, Medical Faculty, Bozok University, Yozgat, Turkey.
3Department of Biochemistry, Medical Faculty, Selcuk University Selcuklu, Konya, Turkey.
4Department of Cardiology, Medical Faculty, Selcuk University, Konya, Turkey.
5Department of Cardiology, Medical Faculty, Dicle University, Diyarbakır, Turkey.
Accepted 14 September, 2024
Abstract
High dose statin medication in acute coronary syndrome cases is a therapy which lowers mortality and morbidity rates. Interleukin-6 (IL-6) is produced in higher amounts in acute myocardial infarction (MI) and facilitates myocardial damage. However, secretion of nitric oxide (NO) is depleted. We aimed to compare the effects of conventional dose (10-40 mg/day) and aggressive dose (80 mg/day) atorvastatin medications on IL- 6 and NO levels in patients with primary percutaneous transluminal coronary angioplasty (PTCA) intervention after acute MI. 50 patients (8 females, 42 males) with the diagnosis of acute MI with ST segment elevation enrolled to the study. Primary PTCA intervention was performed on these patients and consequently either conventional dose (10 to 40 mg/day) or aggressive dose (80 mg/day) atorvastatin medications were given to the patients. Three months later, plasma IL-6 and NO levels were determined and alterations in the groups were evaluated. IL-6 levels decreased from 24.34 ± 12.04 to 11.40 ± 5.79 pg/ ml and from 29.62 ± 17.38 to 12.51 ± 8.95 pg/ml in conventional dose and aggressive dose regimens respectively (p<0.001) . However, NO concentrations increased from 22.90 ± 8.24 to 31.70 ± 7.56 µM in conventional dose and from 19.37 ± 5.60 µM to 34.15 ± 9.60 µM in aggressive dose groups (p < 0.001). The effects of aggressive dose atorvastatin medication on IL -6 and NO levels were similar to conventional dose application in cases with ST segment elevation acute MI.
Key words: Atorvastatin, interleukin-6, nitric oxide, myocardial infarction.