African Journal of Parasitology Research

Full Length Research Paper

The contribution of host cells to dengue virus infectivity

Woraphol Rattanachuen, Lukkana Suksanpaisan, Nitwara Wikan and Duncan R. Smith*

Molecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Thailand.

Accepted 15 April, 2021

Abstract

Dengue virus infections remain a significant worldwide public health problem, causing millions of new infections each year. Transmitted by mosquitoes of the Aedes genus, the virus is capable of replicating in a number of different cells of both mosquito and human origin, but the molecular mechanism of infection remains largely unknown. This study sought to determine if the host cell in which a virus was produced had an effect on its subsequent ability to infect other cells. The study used dengue serotype 1 and 2, propagated in both insect (C6/36) and mammalian (Hep3B liver cells) to infect both C6/36 and Hep3B cells. Results showed clearly that both serotype and host cell modulated the ability of the virus to infect cells.