ISSN 2756-3812
International Journal of Medical Advances and Discovery ISSN: 5414-9203 Vol. 1 (3), pp.029-031, December, 2014. © International Scholars Journals
Review
Challenges in determining the order of nucleotides within a DNA molecule using the DNA technologies
D. A Satish1, E. O Varun2*, Kumar Vikas Singh1, Gupta F. Yunus2, Farhan A.3 and Gowda E.3
1Department of Medicine, Faculty of Science, Anna University, Chennai, India.
2Department of Immunology and Defense Mechanism, School of science, Himachal Pradesh University, Shimla, India.
3Department of Physiology and Biochemistry, Jiwaji University, P.O Box 211, Gwalior, India.
E-mail: [email protected]
Accepted 24 November, 2014
Abstract
The advent of second and third generation DNA sequencing techniqnologies have revolutionized the genomics research. The Single Molecule Sequencing technologies are adequate to minimize occurrence of errors in sequencing. The third generation sequencing technologies could overcome limitations of first and second-generation sequencing technologies. The almost complete human genome sequencing was performed by using single molecular sequencing technologies. Benefits, risks and safeguards associated with the disclosure of information of very intimate kind contained in human genome, were also discussed. The power of whole sequencing for human welfare arises only from associations with medical histories, behavioral characteristics, physical descriptions and genome-environment interactions not from mere knowledge of base pairs.
Key words: DNA sequencing, molecules, behavior, characteristics, physical descriptions.