ISSN 2375-0731
African Journal of Pig Farming ISSN 2375-0731 Vol. 5 (3), pp. 001-007, March, 2017. © International Scholars Journals
Full Length Research Paper
The potential lipolysis function of musclin and its mRNA expression both in Pig adipose tissue and primary adipocyte
Chao Sun*, Yongjia Peng, Dongfeng Jiang and Zhongpin Zhang
College of Animal Science and Technology, Northwest A and F University, Yang Ling 712100, Shaanxi, China.
Accepted 27 September, 2016
Abstract
Musclin is a newly discovered factor and its functions remain to be defined. This study investigated the tissue expression pattern of musclin gene and its potential effect on lipid metabolism. Musclin mRNA levels in adipose, muscle tissues and primary adipocytes were examined by quantitative PCR. The musclin gene expression in adult adipose tissue was significantly higher than that in muscle (p < 0.05), and its expression in young adipose tissue was higher than old one. We further found that in adipose tissue, the expression level of musclin had a negative correlation with FAS gene (p = 0.01), and positive correlation with PPAR gene (p < 0.05). In adipocyte, the expression level of musclin gene had a positive correlation with LPL gene (p < 0.01). Our results suggested that musclin is a potential factor that might play an important role in the regulation of adipogenesis.
Key words: Musclin, adipocyte, adipose tissue, lipid metabolism, expression.