African Journal of Internal Medicine

ISSN 2326-7283

African Journal of Internal Medicine ISSN 2326-7283 Vol. 7 (8), pp. 001-004, August, 2019. © International Scholars Journals

Full Length Research Paper

The effect of short term administration of testosterone on serum growth hormone and body mass index in adult male albino rats

Ayinde Taofeek Olarewaju1, Ojulari Lekan Sheriff1*, Ali-Olufuyi A-Musawir2, Biliaminu Sikiru Abayomi3, Abdulazeez Musbau Ishola3 and Adesina Toluwase Oluwapelumi1

1Department of Physiology, University of Ilorin, Ilorin, Nigeria.

2Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin, Nigeria.

3Department of Chemical Pathology and Immunology, University of Ilorin, Ilorin, Nigeria.

Accepted 10 March, 2019

Abstract

Testosterone is a steroid hormone from the androgen groups, secreted primarily in the testicles of males. Studies have shown that testosterone production will also boost growth. The present study was carried out to study the effect of short-term administration of testosterone on serum growth hormone concentration, body mass index (BMI) and body weight in adult male rats. Twenty-one male rats were divided into three (3) groups of seven (7) rats each; a control group, a low-dose and a high-dose testosterone group. Normal saline was administered intramuscularly to the control group, while 2.5 and 6.25 mg/d of testosterone propionate were administered intramuscularly to the low-dose and high-dose groups, respectively, for fourteen (14) days. The body weight and the length of the rats were recorded for calculation of the body mass index. Blood samples for serum growth hormone assay were collected via cardiac puncture. Results showed a significant (P<0.05) increase in the serum growth hormone concentration in the high dose testosterone group when compared to the control while changes recorded in the BMI and body weight were not significant. It was concluded that testosterone can exert its anabolic effects by acting synergistically with the anabolic effects of growth hormone.

Key words: Testosterone, growth hormone, high-dose, body mass index.

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Ali-Olufuyi A-Musawir on Google Scholar Ali-Olufuyi A-Musawir on Pubmed Biliaminu Sikiru Abayomi on Google Scholar Biliaminu Sikiru Abayomi on Pubmed Abdulazeez Musbau Ishola and Adesina Toluwase Oluwapelumi on Google Scholar Abdulazeez Musbau Ishola and Adesina Toluwase Oluwapelumi on Pubmed Ojulari Lekan Sheriff* on Google Scholar Ojulari Lekan Sheriff* on Pubmed Ayinde Taofeek Olarewaju on Google Scholar Ayinde Taofeek Olarewaju on Pubmed