ISSN 2736-1594
International Journal of Obstetrics and Gynecology ISSN 2326-7234 Vol. 6 (4), pp. 219-222, April, 2018. © International Scholars Journals
Full Length Research Paper
Association of angiotensin converting enzyme gene I/D polymorphism with vitiligo in South Indian population
Debi Dutt1, Nitin Sunil2 and Verma Satya2
¹Department of Endocrinology, Faculty of Medicine, Amity University, Raipur, India
²Department of Gastroenterology, Faculty of Internal Medicine, Kalinga University, Naya Raipur, Chhattisgarh, India.
3Department of Medical oncology, School of Life and Allied Sciences, Naya Raipur, Chhattisgarh, India.
*Corresponding author. E-mail: [email protected].
Accepted 12 February, 2016
Abstract
Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is polygenic disease and associated with autoimmunity. Angiotensin converting enzyme (ACE) is capable of modulating cutaneous neuro-genic inflammation. An insertion/deletion (I/D) polymorphism of a 287-base pair repetitive sequence in intron 16 of the ACE gene was reported to have been associated with autoimmunity and with the development of vitiligo. In our study, the distribution of ACE gene I/D genotype was investigated in a population of 186 South Indian vitiligo patients and 201 healthy controls using polymerase chain reaction genotyping method. The ACE genotype and allele frequency ( ² = 9.576, P= 0.008) ( ² = 10.68, P = 0.001) were significantly different between vitiligo patients and healthy controls.However there was no significant difference between the segmental and non-segmental vitiligo( ² = 0.182, P = 0.91) detected in ACE gene genotype distribution .This study suggests that the ACE genepolymorphism confers susceptibility to vitiligo.
Key words: Angiotensin converting enzyme, gene polymorphism, vitiligo, autoimmunity.