ISSN 2169-303X
International Journal of Medicinal Plants Research ISSN: 2169-303X Vol. 5 (4), pp. 244-250, April, 2016.© International Scholars Journals
Full Length Research Paper
Anthelminthic in vitro efficacy of immature fruits of M. indica for the control of Strongyloides stercoralis.
Mohamed Mahfouz Sharif
Department of Parasitology, Faculty of Pharmacy, October 6 University Cairo, Egypt.
E-mail: [email protected]
Accepted 22 March, 2016
Abstract
Infections with Strongyloides stercoralis and other helminths represent important, yet often neglected issues in developing countries. Indeed, strongyloidiasis can be fatal, but only a few studies provide information regarding its health relevance in Africa. S. stercoralis is an intestinal nematode that can persist in the human host for decades after the initial infection and can progress to fulminant hyperinfection syndrome in immunocompromised hosts, and the rapid development of nematode resistance to anthelminthics has limited the success of control in several countries, stimulating the search for alternatives. In this study, extracts of immature fruits of the mango Mangifera indica L. were evaluated for inhibition of larval development. In the phytochemical analyses, tannins and flavonoids were the metabolites identified. Aqueous extracts of immature fruits at 100 mg ml−1 showed 100% inhibition of larval development. In vitro results indicate that this fruit could assist S. stercoralis control.
Key words: Strongyloides stercoralis, strongyloidiasis, helminthes, host.