African Journal of Parasitology Research

African Journal of Parasitology Research Vol. 2 (8), pp. 125-134, August, 2015. © International Scholars Journals

Full Length Research Paper

A study of malaria vectors resistance to several insecticides and the need for the development of alternative insecticides for use in vector control programs

*Ezra O. Legend, Micheal Noam Perelman and Warren E.  Pound

Department of Disease Control and Prevention, University of Pennsylvania, Philadelphia, Pennsylvania.

*Corresponding author. E-mail: [email protected]

Accepted 19 March, 2015

Abstract

Malaria vectors have acquired widespread resistance to several insecticides; thus, there is a critical need for the development of alternative insecticides for use in vector control programs. The mosquito toxicity of a novel insecticide/repellent consisting of medium-chain carbon fatty acids (C8910) was examined. Determination of LCD₅₀ and LCD₉₀ was made against six colony-reared Anopheles species using probit analysis on mortality data generated by Centers for Disease Control and Prevention bottle bioassays. Eight different concentrations of C8910+silicone oil provided an LCD₅₀ ranging from 55.4 (44.2 to 65.9) in Anopheles minimus to 132.6 (92.8 to 301.3) in Anopheles dirus. Similarly, LCD₉₀ varied from 138.5 (107.9 to 207.9) to 1228.8 (449.8 to 21400), respectively. Further development of C8910 and similar compounds could provide vector control specialists novel, environmentally-safe insecticides for controlling insect disease vectors.

Key words: LCD₅₀, LCD₉₀, bottle bioassay, C8910, silicone, malaria, Anopheles.